Regular Article

Mechanical modeling of growth applied to Saccharomyces cerevisiae yeast cells

¹ Sorbonne Université, Institut Jean Le Rond d’Alembert, CNRS, UMR 7190
² Université Gustave Eiffel, MAST/EMGCU

e-mail: zeinab.awada@sorbonne-universite.fr

Received: 11 December 2022
Accepted: 25 July 2023

Abstract

A theoretical and numerical model is developed to describe the growth of Saccharomyces cerevisiae yeasts. This kind of cells is considered here as an axisymmetrical and deformable structure, the inner surface of which is continuously acted upon by a high turgor pressure. Due to the small ratio between the cellwall thickness and the cell radius, a structural shell approach is used. Moreover, the finite strain range is assumed because of the soft nature of these cells. The adopted kinematics is herein based on the multiplicative decomposition of the deformation gradient into an elastic part F^e and an irreversible part related to the growth F^g, i.e. F = F^eF^g. The reversible response is described using an hyperelastic model of the Ogden type. In accordance with continuum thermodynamics requirements, a criterion is introduced to control the evolution of the growth phenomenon. In this latter two parameters are involved: a growth stress-like threshold, and a growth characteristic time. Embedded within the finite element framework, an illustrative example shows the growth phenomenon of spherical cells going from yeast bud emergence to the step just before cell division. A parametric study highlights the influence of the above mentioned parameters on the cell responses.